Thermo Fisher Scientific Human SYPL2 Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 15 amino acids near the carboxy terminus of human SYPL2.
PEP-0890 can be used as a blocking peptide with polyclonal antibody PA5-20776.

Target Information

SYPL2, also known as Mitsugumin 29, was initially identified as a transmembrane protein from the triad junction in skeletal muscle that has significant homology with members of the synaptophysin family.
SYPL2 is thought to participate in the excitation-contraction coupling process of skeletal muscle, as SYPL2-deficient mice showed reduced muscle contractile force, altered triad junction structure, and increased susceptibility to fatigue.
It plays a critical role in muscle Ca²⁺ signaling by regulating store-operated Ca²⁺ entry and interacts with the ryanodine receptor (RyR), influencing intracellular Ca²⁺ homeostasis through changes in the RyR/Ca²⁺ release function.
Co-expression of SYPL2 and RyR in cultured cells leads to apoptotic cell death resulting from depletion of Ca²⁺ from intracellular stores.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.