Thermo Fisher Scientific Human SYPL2 Synthetic Peptide
인간 SYPL2 단백질의 카복시 말단 15개 아미노산 서열에 해당하는 합성 펩타이드. PA5-20776 항체의 블로킹 펩타이드로 사용 가능. 순도 높은 액상 형태로 제공되며, PBS 버퍼(pH 7.2, 0.1% BSA, 0.02% sodium azide) 내 보관. 연구용으로만 사용.
- 카탈로그번호
- PEP0890
- 카테고리
- Amides
- 판매단위
- pk
카탈로그
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 15 amino acids near the carboxy terminus of human SYPL2.
PEP-0890 can be used as a blocking peptide with polyclonal antibody PA5-20776.
Target Information
SYPL2, also known as Mitsugumin 29, was initially identified as a transmembrane protein from the triad junction in skeletal muscle that has significant homology with members of the synaptophysin family.
SYPL2 is thought to participate in the excitation-contraction coupling process of skeletal muscle, as SYPL2-deficient mice showed reduced muscle contractile force, altered triad junction structure, and increased susceptibility to fatigue.
It plays a critical role in muscle Ca²⁺ signaling by regulating store-operated Ca²⁺ entry and interacts with the ryanodine receptor (RyR), influencing intracellular Ca²⁺ homeostasis through changes in the RyR/Ca²⁺ release function.
Co-expression of SYPL2 and RyR in cultured cells leads to apoptotic cell death resulting from depletion of Ca²⁺ from intracellular stores.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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