Thermo Fisher Scientific ASXL1 Monoclonal Antibody (11I4)
ASXL1 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Western blot 및 Flow cytometry에 적합합니다. 동결건조 형태로 제공되며 재구성 시 500 µg/mL 농도 유지. 핵 수용체 매개 전사 조절 연구에 활용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 0.1–0.5 µg/mL
Flow Cytometry (Flow)
- Tested Dilution: 1–3 µg per 1×10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 11I4 |
| Immunogen | A synthetic peptide corresponding to a sequence of human ASXL1 (KKERTWAEA ARLVLENYSDAPMTPKQILQVIEAE) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 500 µg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2884072 |
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Target Information
Probable Polycomb group (PcG) protein involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG).
Acts as coactivator of RARA and RXRA through association with NCOA1.
Acts as corepressor through recruitment of KDM1A and CBX5 to target genes in a cell-type specific manner; the function seems to involve differential recruitment of methylated histone H3 to respective promoters.
Acts as corepressor for PPARG and suppresses its adipocyte differentiation-inducing activity.
Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at Lys-119 (H2AK119ub1).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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