Thermo Fisher Scientific ARFGAP1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

Immunocytochemistry (ICC/IF)

1:100-1:500

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human ARFGAP1(Accession Q8N6T3), corresponding to amino acid residues D303-D353. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:ARFGAP1,uniProtId:Q8N6T3-1,ncbiNodeId:9606,antigenRange:303-353,antigenLength:406,antigenImageFileName:PA5-101408_ARFGAP1_Q8N6T3-1_Rabbit.svg,antigenImageFileNamePDP:PA5-101408_ARFGAP1_Q8N6T3-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2850844

Product Specific Information

Antibody detects endogenous levels of total ARFGAP1.

Target Information

ArfGAP1 is a 406 amino acid containing regulatory protein with an Arf-GAP domain known to be involved in the activation of the GTPase activity of ADP ribosylation factor (ARF). ArfGAP1, a GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1), promotes the hydrolysis of ARF1-bound GTP and is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles thus playing an important role in membrane trafficking and/or vesicle transport. Dissociation of the coat proteins is required for the fusion of these vesicles with target compartments. The activity of this protein is stimulated by phosphoinosides and inhibited by phosphatidylcholine. Two transcript variants encoding different isoforms have been reported. Ubiquitous expression of ArfGAP1 is seen in most tissues.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.