Thermo Fisher Scientific PPP2R1B Polyclonal Antibody, MaxPab

Applications

• Western Blot (WB): 1:500–1:1,000 dilution

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MAGASELGTG PGAAGGDGDD SLYPIAVLID ELRNEDVQLR LNSIKKLSTI ALALGVERTR SELLPFLTDT IYDEDEVLLA LAEQLGNFTG LVGGPDFAHC LLPPLENLAT VEETVVRDKA VESLRQISQE HTPVALEAYF VPLVKRLASG DWFTSRTSAC GLFSVCYPRA SNAVKAEIRQ QFRSLCSDDT PMVRRAAASK LGEFAKVLEL DSVKSEIVPL FTSLASDEQD SVRLLAVEAC VSIAQLLSQD DLETLVMPTL RQAAEDKSWR VRYMVADRFS ELQKAMGPKI TLNDLIPAFQ NLLKDCEAEV RAAAAHKVKE LGENLPIEDR ETIIMNQILP YIKELVSDTN QHVKSALASV IMGLSTILGK ENTIEHLLPL FLAQLKDECP DVRLNIISNL DCVNEVIGIR QLSQSLLPAI VELAEDAKWR VRLAIIEYMP LLAGQLGVEF FDEKLNSLCM AWLVDHVYAI REAATNNLMK LVQKFGTEWA QNTIVPKVLV MANDPNYLHR MTTLFCINAL SEACGQEITT KQMLPIVLKM AGDQVANVRF NVAKSLQKIG PILDTNALQG EVKPVLQKLG QDEDMDVKYF AQEAISVLAL A

Target Information

In eukaryotes, the phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential regulatory mechanism of various cellular functions including division, homeostasis, and apoptosis. Protein phosphatases are key players in this process.

The protein phosphatase (PP) holoenzyme generally forms a trimeric complex composed of:

• A regulatory subunit
• A variable subunit
• A catalytic subunit

Four major families of protein phosphatase catalytic subunits have been identified:

• PP1
• PP2A
• PP2B (calcineurin)
• PP2C
  Additionally, PPX (PP4) is a putative member of a novel PP family.

The PP2A family includes subfamily members PP2A alpha and PP2A beta. The PP2A catalytic subunit associates with various regulatory subunits such as:

• PP2A-A alpha and -A beta
• PP2A-B alpha and -B beta
• PP2A-C alpha and -C beta
• PP2A-B56 alpha and -B56 beta

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.