Thermo Fisher Scientific GLE1 Polyclonal Antibody
Human GLE1 단백질을 인식하는 Rabbit Polyclonal 항체로, WB 및 ELISA에 사용 가능. 정제된 액상 형태로 제공되며, PBS/glycerol buffer에 보관. 세포질 및 핵공동 복합체에서 GLE1 단백질 검출에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–300 of human GLE1 (NP_0010037221) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.16 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805341 |
Product Specific Information
Immunogen sequence:
MPSEGRCWET LKALRSSDKG RLCYYRDWLL RREDVLEECM SLPKLSSYSG WVVEHVLPHM QENQPLSETS PSSTSASALD QPSFVPKSPD ASSAFSPASP ATPNGTKGKD ESQHTESMVL QSSRGIKVEG CVRMYELVHR MKGTEGLRLW QEEQERKVQA LSEMASEQLK RFDEWKELKQ HKEFQDLREV MEKSSREALG HQEKLKAEHR HRAKILNLKL REAEQQRVKQ AEQERLRKEE GQIRLRALYA LQEEMLQLSQ QLDASEQHKA LLKVDLAAFQ TRGNQLCSLI SGIIRASSES
Positive Samples: Jurkat
Cellular Location: Cytoplasm, Nucleus, nuclear pore complex
Target Information
Proper expression of gene products in eukaryotic cells relies on efficient transport of mRNA molecules out of the nucleus. GLE1 is an essential mRNA export factor in both human and yeast cells. It associates with the nuclear pore complex (NPC) through hCG1 and NUP155 in mammalian cells and, in conjunction with inositol hexakisphosphate (IP6), stimulates Dbp5 (a DEAD-box helicase family member), triggering mRNP remodeling and facilitating RNA export from the nucleus.
Mutations in GLE1 that cause mRNA export defects can lead to human diseases. At least three isoforms of GLE1 are known to exist.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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