Thermo Fisher Scientific Human CHCHD6 Synthetic Peptide
인간 CHCHD6 단백질의 C-말단 17개 아미노산 서열 기반 합성 펩타이드입니다. PA5-34486 항체의 차단 펩타이드로 사용 가능합니다. 미토콘드리아 단백질 복합체 연구에 적합하며, -20°C에서 보관합니다.
- 카탈로그번호
- PEP1528
- 판매단위
- pk
카탈로그
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 17 amino acids near the carboxy terminus of human CHCHD6.
PEP-1528 can be used as a blocking peptide with polyclonal antibody PA5-34486.
Target Information
CHCHD6 is a member of a family of proteins containing a conserved (coiled coil 1)-(helix 1)-(coiled coil 2)-(helix 2) domain and has been observed in a complex with the mitochondrial proteins mitofilin, SAM50, metaxins 1 and 2, and CHCHD3.
CHCHD6 knockdown causes severe defects in mitochondrial cristae morphology as well as reductions in cell growth, ATP production, and oxygen consumption.
This decrease of CHCHD6 also led to a reduction in mitofilin protein levels, while a knockdown of mitofilin resulted in a reduced level of CHCHD6, suggesting coordinate regulation between these two proteins.
CHCHD6 knockdown in human cancer cells enhances their sensitivity to genotoxic anticancer drugs, suggesting that CHCHD6 may be a potential therapeutic anti-tumor target.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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