Thermo Fisher Scientific MECP2 Monoclonal Antibody (2E8)
MECP2 단백질을 인식하는 Thermo Fisher Scientific의 단일클론 항체(2E8). Western blot 및 ELISA에 적합하며 인간 시료에 반응. 액상 형태, 보존제 없음, -20°C 보관. 연구용으로만 사용 가능.
- 카탈로그번호
- H00004204-M04A
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
ELISA
- Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2E8 |
| Immunogen | MECP2 (AAH11612, 81 a.a. approximately 170 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Storage Buffer | Ascites |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
PKQRRSIIRD RGPMYDDPTL PEGWTRKLKQ RKSGRSAGKY DVYLINPQGK AFRSKVELIA YFEKVGDTSL DPNDFDFTVT GRGSPSRREQ
Target Information
MECP2 belongs to a family of nuclear proteins (including MBD1, MBD2, MBD3, and MBD4) that have a methyl-CpG binding domain. MECP2 binds specifically to methylated DNA, a major modification in eukaryotic genomes essential for mammalian development. It can repress transcription from methylated gene promoters. Unlike other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensable in stem cells but essential for embryonic development. Mutations in the MECP2 gene cause most cases of Rett syndrome, a progressive neurological developmental disorder and a common cause of mental retardation in females.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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