Thermo Fisher Scientific MECP2 Monoclonal Antibody (2E8)

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

ELISA

• Tested Dilution: 1:500–1:1,000

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
PKQRRSIIRD RGPMYDDPTL PEGWTRKLKQ RKSGRSAGKY DVYLINPQGK AFRSKVELIA YFEKVGDTSL DPNDFDFTVT GRGSPSRREQ

Target Information

MECP2 belongs to a family of nuclear proteins (including MBD1, MBD2, MBD3, and MBD4) that have a methyl-CpG binding domain. MECP2 binds specifically to methylated DNA, a major modification in eukaryotic genomes essential for mammalian development. It can repress transcription from methylated gene promoters. Unlike other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensable in stem cells but essential for embryonic development. Mutations in the MECP2 gene cause most cases of Rett syndrome, a progressive neurological developmental disorder and a common cause of mental retardation in females.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.