Thermo Fisher Scientific IMPACT Polyclonal Antibody
인간 IMPACT 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot 및 IHC(P) 분석에 최적화됨. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성을 제공. 연구용으로만 사용 가능하며, 장기 보관 시 -20°C에서 보관 권장.
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Thermo Fisher Scientific IMPACT Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human IMPACT. Recombinant protein control fragment (Product #RP-98247) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2642710 |
Product Specific Information
Immunogen sequence:
VSRWYGGILL GPDRFKHINN CARNILVEKN YTNSPEESSK ALGKNKKVRK DKKRNEH
Highest antigen sequence identity to orthologs:
- Mouse: 84%
- Rat: 84%
Target Information
Translational regulator that ensures constant high levels of translation under stress conditions such as amino acid starvation, UV-C irradiation, proteasome inhibitor treatment, and glucose deprivation. Acts as a negative regulator of EIF2AK4/GCN2 kinase activity by impairing GCN1-mediated activation, reducing eIF-2-alpha phosphorylation, and maintaining protein synthesis. May regulate translation in neuronal cells under amino acid starvation by preventing GCN2 activation and ATF4 synthesis. Plays a role in neuronal differentiation by stimulating neurite outgrowth.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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