Thermo Fisher Scientific BST2 Monoclonal Antibody (1C3)
BST2 단백질을 인식하는 Rabbit monoclonal antibody(1C3)로, Western blot, IHC, Flow cytometry에 적합합니다. 인간 BST2(aa100-161) 합성 펩타이드로부터 유래했으며, 1 mg/mL 농도의 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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- BSM-54196R
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:400 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1C3 |
| Immunogen | Synthetic peptide corresponding to human BST2 aa 100–161 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | −20°C |
| Shipping Conditions | Wet ice |
Target Information
BST2 (also known as CD317, HM1.24 antigen, DAMP-2, tetherin) is an integral membrane protein involved in B-cell development and growth. Expression of BST2 on fibroblast cell lines supports stromal cell-dependent growth of pre-B-cell lines. BST2 is expressed throughout B-cell maturation, as well as in T-cells, monocytes, NK cells, dendritic cells, and myeloma cells.
Research indicates BST2 inhibits retrovirus release from human cells, a process counteracted by the HIV-1 Vpu protein. BST2 retains virions on cell surfaces or internalizes them into BST2-positive compartments. Depletion of BST2 abolishes the requirement for Vpu, suggesting potential therapeutic implications for HIV/AIDS. BST2 dysfunction has also been associated with stomatitis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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