Thermo Fisher Scientific UAP1L1 Polyclonal Antibody
Thermo Fisher Scientific의 UAP1L1 폴리클로날 항체로, Mouse UAP1L1 단백질(aa 360-409) 영역에 대응하는 합성 펩타이드로 제작됨. Western blot에 최적화되어 있으며, Rabbit IgG 형식의 액상 항체. PBS buffer에 2% sucrose 포함, -20°C 보관 권장.
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Applications
- Western Blot (WB): Tested at 1.0 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to a region of mouse UAP1L1 (aa 360–409) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2691298 |
Product Specific Information
This target displays homology in the following species:
Dog: 86%
Guinea Pig: 93%
Horse: 93%
Human: 100%
Mouse: 100%
Rat: 100%
Zebrafish: 83%
Target Information
UAP1 is a 56 kDa isoform that catalyzes the final step of UDP-N-acetylglucosamine (UDP-GlcNAc) biosynthesis from fructose-6-phosphate. UDP-GlcNAc serves as a key precursor in N-linked glycosylation and GPI-anchor formation of cellular proteins.
Crystallization studies revealed that UAP1 consists of a large central core flanked by two smaller domains, with the central domain exhibiting an alpha/beta Rossmann fold structure.
Northern blot analysis detected abundant expression of UAP1 in testis and sperm, with low expression in placenta, muscle, and liver. It is implicated in antibody-mediated infertility in males.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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