Thermo Fisher Scientific LASS6 Monoclonal Antibody (6B8)

Applications

Western Blot (WB)

• Tested Dilution: 1–5 µg/mL

ELISA

• Tested Dilution: 0.1 ng/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
PCAIALNIQA NGPQIAPPNA ILEKVFTAIT KHPDEKRLEG LSKQLDWDVR SIQRWFRQRR NQEKPSTLTR

Target Information

Longevity assurance genes (LAGs) represent a subgroup of the homeobox gene family. Five mammalian homologs have been reported, and the corresponding proteins have been investigated for their key role in ceramide synthesis. Members of the LAG family are also involved in cell growth regulation and cancer differentiation.
LASS6 may be involved in sphingolipid synthesis or its regulation. It interacts with ATP6V0C, ASGR1, ASGR2, and SLC22A1/OCT1. Localized to the nuclear membrane as a multi-pass membrane protein, it may also be expressed on the endoplasmic reticulum membrane. Glycosylation on Asn-18 is not necessary for function.
Like other LAG family members, the LASS6 protein contains a homeodomain and LAG1 domain and displays highest homology to LASS5. The corresponding gene is localized to human chromosome 2q24.3, spanning approximately 318 kb. Sequences in mouse and zebrafish suggest conservation of LASS6 in vertebrates. LASS6 is broadly expressed in various tissues and has been implicated in cancer differentiation and early embryonic development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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