Thermo Fisher Scientific USP5 Polyclonal Antibody
Thermo Fisher Scientific의 USP5 Polyclonal Antibody는 인간 및 생쥐 시료에 반응하며 Western blot 등에 적합합니다. 항원 친화 크로마토그래피로 정제된 액상 항체로, 4°C 단기 보관 및 -20°C 장기 보관이 가능합니다. USP5 단백질 연구용으로 설계된 고품질 항체입니다.
- 카탈로그번호
- PA530265
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 59–289 of Human USP5 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.28 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M tris glycine, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2547739 |
Product Specific Information
- Recommended positive controls: A431, Raji, mouse brain
- Predicted reactivity: Mouse (97%), Rat (96%), Rhesus Monkey (100%), Bovine (97%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
USP5 (ubiquitin carboxyl-terminal hydrolase 5) cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers.
It is involved in unanchored Lys-48-linked polyubiquitin disassembly and also binds linear and Lys-63 linked polyubiquitin with lower affinity.
Knock-down of USP5 causes accumulation of p53/TP53 and increases p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates competes with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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