Thermo Fisher Scientific TNNI2 Monoclonal Antibody (7G2)
Human skeletal muscle Troponin I 검출용 Mouse monoclonal antibody (Clone 7G2). Western blot, ELISA, Affinity Purification에 사용 가능. Protein A로 정제된 액상형, 4°C 보관. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: Assay-dependent
ELISA
- Tested Dilution: Assay-dependent
- Publications: 1 publication available
Affinity Purification (AP)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 7G2 |
| Immunogen | Full length Human skeletal Troponin I (TNNI2, UniProt ID: P48788-1, antigen range 1–182) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 3.9 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2206107 |
Additional Formats
Product Specific Information
MA1-22704 detects skeletal muscle Troponin I in Human samples.
Target Information
This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C, and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for calcium-dependent regulation of striated muscle contraction.
Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. In addition to muscle tissues, this protein is found in corneal epithelium and cartilage, where it inhibits angiogenesis to suppress tumor growth and metastasis, and in mammary gland, where it functions as a co-activator of estrogen receptor-related receptor alpha. It also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause myopathy and distal arthrogryposis type 2B. Alternatively spliced transcript variants have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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