Thermo Fisher Scientific hnRNP M1-M4 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total hnRNP M.

Target Information

Heterogeneous nuclear ribonucleoproteins (hnRNPs) are proteins that bind directly to nascent RNA polymerase II transcripts and play a key role in transcript-specific packaging and alternative splicing of pre-mRNAs.
The M1–M4 proteins form a cluster of four abundant hnRNPs that act as pre-mRNA binding proteins in vivo and bind strongly to poly(G) and poly(U) RNA homopolymers in vitro.
These proteins belong to the ribonucleoprotein consensus sequence family and share similarity with a hypothetical RNA-binding protein from Saccharomyces cerevisiae.
They contain a unique hexapeptide-repeat region rich in methionine and arginine residues (MR repeat motif), resembling a repeat found in the 64 kDa subunit of cleavage stimulation factor involved in 3′-end maturation of pre-mRNAs.
Proteins immunologically related to M exist across diverse eukaryotes from human to yeast.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.