Thermo Fisher Scientific DCC Polyclonal Antibody
DCC 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot, IHC, ICC/IF, Flow Cytometry에 사용 가능. Human 및 Mouse 시료에 반응하며 항원 친화 크로마토그래피로 정제됨. 1 mg/mL 농도의 액상 형태로 제공되며, 연구용으로만 사용.
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Applications
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | — |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent | — |
| Immunocytochemistry (ICC/IF) | Assay-dependent | — |
| Flow Cytometry (Flow) | Assay-dependent | — |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human Netrin receptor DCC aa 21–299/1447 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS (pH 7.4) with 0.2% BSA, 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2932599 |
Target Information
This gene encodes a netrin 1 receptor. The transmembrane protein belongs to the immunoglobulin superfamily of cell adhesion molecules and mediates axon guidance of neuronal growth cones toward sources of netrin 1 ligand. The cytoplasmic tail interacts with tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts and induces apoptosis in the absence of ligand. It functions as a tumor suppressor and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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