Thermo Fisher Scientific UBASH3A Polyclonal Antibody
Human UBASH3A 단백질을 인식하는 Rabbit Polyclonal 항체로, ICC/IF에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS와 글리세롤 용액 형태로 제공됩니다. 단기 4°C, 장기 -20°C 보관 권장. 연구용 전용 제품입니다.
- 카탈로그번호
- PA5111061
- 판매단위
- pk
카탈로그
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human UBASH3A. Recombinant protein control fragment (Product # RP-95890) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2856472 |
Product Specific Information
Immunogen sequence:
LYSRDMRFVH YQTLRALFQY KPQNVDELTL SPGDYIFVDP TQQDEASEGW VIGISQRTGC RGFLPENYTD RASESDTWVK HRMY
Target Information
TULA (T cell ubiquitin ligand, UBASH3A, ubiquitin associated and SH3 domain containing A), also known as STS-2 or CLIP4, is a 661 amino acid protein localized in both the nucleus and cytoplasm. It contains one SH3 domain and one UBA domain.
Highly expressed in thymus, bone marrow, spleen, and peripheral blood leukocytes, TULA forms homodimers or homo-oligomers that interfere with receptor-type tyrosine kinase degradation, promoting accumulation of activated receptors on the cell surface.
TULA participates in an EGFR- and Cbl-containing complex interacting with ubiquitinated proteins. The gene encoding TULA, located on human chromosome 21, may be implicated in type I diabetes pathogenesis. Multiple isoforms exist due to alternative splicing events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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