Thermo Fisher Scientific TRBP1 Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:20–1:50

Immunocytochemistry (ICC/IF)

• Tested Dilution: 0.25–2 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
MNELNSVSDL DRCHLYLMVL TELINLHLKV GWKRGNPIWR VISLLKNASI QHLQEMDSGQ EPTVGSQIQR VVSMAALAMV CEAIDQKPEL QLDSLHAG

• Highest antigen sequence identity to the following orthologs:
  • Mouse: 64%
  • Rat: 59%

Target Information

The human trans-activation response (TAR) RNA binding protein 1 (TRBP1) was initially identified as a protein that binds to the HIV-1 TAR RNA and activates the long terminal repeat (LTR) expression in the absence and presence of the viral trans-activator Tat. This binding is enhanced by co-factors such as elongation factor 1-a (EF-1-a), polypyrimidine tract-binding protein (PTB), and the chaperonin-like protein stimulator of TAR RNA-binding proteins (SRB).
TRBP1 may act to disengage RNA polymerase II from TAR during transcriptional elongation if the RNA polymerase stalls at the TAR during transcriptional elongation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.