Thermo Fisher Scientific DYNC1H1 Polyclonal Antibody
DYNC1H1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. Western blot 및 IHC(P) 검증 완료. 항원 친화 크로마토그래피로 정제, PBS/glycerol 버퍼에 보관. 인간 시료 반응성 확인.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human DYNC1H1. Recombinant protein control fragment (Product # RP-89038) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2640843 |
Product Specific Information
Immunogen sequence:
RSLETCMYDH KTFSEILNRV QKAVDDLNLH SYSNLPIWVN KLDMEIERIL GVRLQAGLRA WTQVLLGQAE DKAEVDMDTD APQVSHKPGG EPKIKNVVHE LRITNQVIYL NPPIEECRYK LYQEMFAWKM VVLSLPRIQS QR
Highest antigen sequence identity to the following orthologs:
- Mouse: 100%
- Rat: 99%
Target Information
ZEB2, initially identified as Smad interacting-protein 1, is normally located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Like the homologous ZEB1, ZEB2 inhibits the transcription of the E-cadherin gene and induces epithelial-mesenchymal transition, a genetic program controlling cell migration during embryonic development and wound healing. ZEB2 can also protect cells from DNA damage-induced apoptosis, suggesting that its expression may contribute to tumor progression. Recent evidence has shown that ZEB2 is often observed in the cytoplasm in numerous cancer tissues, indicating that its localization may be regulated in normal and tumor tissues. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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