Thermo Fisher Scientific Phospho-Rb (Ser612) Polyclonal Antibody
인간 Rb 단백질의 Ser612 인산화 형태를 특이적으로 검출하는 폴리클로날 항체입니다. Western blot에 적합하며, 1:1,000 희석으로 사용 가능합니다. 고순도 친화 크로마토그래피 정제, 액상 형태로 제공되며 -20°C에서 보관합니다.
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Applications
- Western Blot (WB): Tested dilution 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human Retinoblastoma (Phospho-Ser612) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2662403 |
Product Specific Information
Phospho-Rb (Ser612) Polyclonal Antibody detects endogenous levels of Rb only when phosphorylated at Ser612.
Target Information
Rb is a tumor suppressor nuclear phosphoprotein capable of binding to DNA. It is phosphorylated on serine and threonine residues. It forms complexes with SV40 large T antigen, adenovirus E1A, and human papilloma virus-16 E. Rb protein may act by regulating transcription, and loss of its function leads to uncontrolled cell growth. Aberrations in the RB gene have been implicated in various cancers including breast, colon, prostate, kidney, nasopharynx, and leukemia.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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