Thermo Fisher Scientific GPR37 Polyclonal Antibody

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Human GPR37

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2662077

Product Specific Information

Immunogen sequence: RWKGARGQEPS ETLGRGNPTA LQLFLQISEE EEKGPRGAGI SGRSQEQSVK TVPGASDLFY WPRRAGKLQG SHHKPLSKTA NGLAGHEGWT IALPGRALAQ NGSLGEGIHE PGGPRRGNST NRRVRLKNPF YPLTQESYGA

Highest antigen sequence identity to the following orthologs - mouse 59%, rat 62%.

Target Information

Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson disease identified to date. The function of Park2 is not well-known; however, it may play a role in the ubiquitin-mediated proteolytic pathway. Mutations in this gene are known to cause autosomal recessive juvenile parkinsonism. Alternative splicing of this gene produces three known products of undetermined function. Panneuronal expression of Parkin substrate Pael-R causes age-dependent selective degeneration of Drosophila dopaminergic (DA) neurons; coexpression of Parkin degrades Pael-R and suppresses its toxicity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.