ELK Biotechnology DSC2 rabbit pAb
DSC2 단백질을 인식하는 토끼 폴리클로날 항체로, WB와 ELISA에 적합합니다. 인간 및 생쥐 시료에 반응하며, 세포막 및 데스모좀 단백질 연구에 활용됩니다. -20°C에서 1년 보관 가능합니다.
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제품명
DSC2 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:500–2000, ELISA 1:5000–20000 |
| Immunogen | Synthesized peptide derived from human protein (AA range: 150–230) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 99 kDa |
| Gene ID (Human) | 1824 |
| Human Swiss-Prot No. | Q02487 |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein; Cell junction, desmosome |
| Species Reactivity | Human; Mouse |
Background
This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
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