ELK Biotechnology PARP9 rabbit pAb
PARP9 rabbit pAb는 인간 및 마우스 시료에서 사용 가능한 다클론 항체로, WB 및 ELISA에 적합합니다. 세포질과 핵에서 발현되는 PARP9 단백질을 인식하며, 고순도 IgG 형태로 제공됩니다. 장기 보관 시 -20°C에서 안정합니다.
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제품명
PARP9 rabbit pAb
적용 분야
- Western Blot (WB)
- ELISA
권장 희석 배수
- WB: 1:500–1:2000
- ELISA: 1:5000–1:20000
제품 정보
| 항목 | 내용 |
|---|---|
| Immunogen | Synthesized peptide derived from human protein (AA range: 450–530) |
| Storage | -20°C / 1 year |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 93 kDa |
| Gene ID (Human) | 83666 |
| Human Swiss-Prot No | Q8IXQ6 |
| Species Reactivity | Human, Mouse |
세포 내 위치
Cytoplasm, cytosol, and nucleus. Shuttles between the nucleus and cytosol (PubMed:16809771). Translocates to the nucleus in response to IFNG or IFNB1 stimulation (PubMed:26479788). Export to the cytosol depends on interaction with DTX3L (PubMed:16809771). Localizes at sites of DNA damage in a PARP1-dependent manner (PubMed:23230272, PubMed:28525742).
배경 정보
Catalytic activity: NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
Overexpressed at significantly higher levels in fatal high-risk diffuse large B-cell lymphomas (DLBCL) compared to cured low-risk tumors. Overexpression in B-cell lymphoma transfectants may promote malignant B-cell migration.
Contains 1 PARP catalytic domain and 2 Macro domains.
Interacts with BBAP.
Expressed in lymphocyte-rich tissues such as spleen, lymph nodes, peripheral blood lymphocytes, and colonic mucosa. Also expressed in nonhematopoietic tissues such as heart and skeletal muscle. Isoform 2 is the predominant form.
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