ELK Biotechnology PARP9 rabbit pAb

제품명

PARP9 rabbit pAb

적용 분야

• Western Blot (WB)
• ELISA

권장 희석 배수

• WB: 1:500–1:2000
• ELISA: 1:5000–1:20000

제품 정보

세포 내 위치

Cytoplasm, cytosol, and nucleus. Shuttles between the nucleus and cytosol (PubMed:16809771). Translocates to the nucleus in response to IFNG or IFNB1 stimulation (PubMed:26479788). Export to the cytosol depends on interaction with DTX3L (PubMed:16809771). Localizes at sites of DNA damage in a PARP1-dependent manner (PubMed:23230272, PubMed:28525742).

배경 정보

Catalytic activity: NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
Overexpressed at significantly higher levels in fatal high-risk diffuse large B-cell lymphomas (DLBCL) compared to cured low-risk tumors. Overexpression in B-cell lymphoma transfectants may promote malignant B-cell migration.
Contains 1 PARP catalytic domain and 2 Macro domains.
Interacts with BBAP.
Expressed in lymphocyte-rich tissues such as spleen, lymph nodes, peripheral blood lymphocytes, and colonic mucosa. Also expressed in nonhematopoietic tissues such as heart and skeletal muscle. Isoform 2 is the predominant form.