ELK Biotechnology MIS rabbit pAb
MIS rabbit polyclonal antibody for WB and ELISA applications. Recognizes human MIS protein involved in TGF-beta signaling. High specificity and sensitivity with dilution flexibility. Long-term storage at -20°C for stable performance.
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ELK Biotechnology MIS rabbit pAb
제품 개요
MIS rabbit polyclonal antibody는 인간 MIS 단백질을 인식하며, TGF-beta 수퍼패밀리 리간드 연구에 사용됩니다. WB 및 ELISA에 적합하며, 높은 특이성과 안정성을 제공합니다.
제품 스펙
| 항목 | 내용 |
|---|---|
| Product name | MIS rabbit pAb |
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:500–2000, ELISA 1:5000–20000 |
| Immunogen | Synthesized peptide derived from human protein (AA range: 380–460) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 61 kD |
| GeneID (Human) | 268 |
| Human Swiss-Prot No | P03971 |
| Cellular Localization | Secreted |
| Species Reactivity | Human; Rat; Mouse |
Background
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate N- and C-terminal cleavage products that homodimerize and associate to form a biologically active noncovalent complex. This complex binds to the anti-Mullerian hormone receptor type 2 and causes the regression of Mullerian ducts in the male embryo that would otherwise differentiate into the uterus and fallopian tubes. This protein also plays a role in Leydig cell differentiation and function and follicular development in adult females. Mutations in this gene result in persistent Mullerian duct syndrome. [provided by RefSeq, Jul 2016]
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