ELK Biotechnology WT1 rabbit pAb
인간, 생쥐, 랫트에 반응하는 WT1 rabbit polyclonal antibody로, WB 및 ELISA에 적합합니다. 핵 및 세포질 위치에서 WT1 단백질을 검출하며, 안정적인 IgG 형식으로 -20°C에서 1년간 보관 가능합니다.
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제품명
WT1 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:500–2000, ELISA 1:5000–20000 |
| Immunogen | Synthesized peptide derived from human protein (AA range: 310–390) |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 49 kD |
| GeneID (Human) | 7490 |
| Human Swiss-Prot No | P19544 |
| Species Reactivity | Human; Rat; Mouse |
| Storage | -20°C / 1 year |
| Host | Rabbit |
세포 내 위치
Nucleus, nucleolus, cytoplasm. Isoforms lacking the KTS motif have a diffuse nuclear location (PubMed:15520190). Shuttles between nucleus and cytoplasm.
- Isoform 1: Nucleus speckle
- Isoform 4: Nucleus, nucleoplasm
배경 정보
This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It plays an essential role in the normal development of the urogenital system and is mutated in a subset of patients with Wilms tumor.
WT1 exhibits complex tissue-specific and polymorphic imprinting patterns, with biallelic and monoallelic expression from maternal and paternal alleles in different tissues. Multiple transcript variants are described, some using a non-AUG (CUG) translation initiation codon upstream of the first AUG.
According to PMID:7926762, WT1 mRNA undergoes RNA editing in human and rat, which is tissue-restricted and developmentally regulated. (RefSeq, Mar 2015)
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