ELK Biotechnology TNKS1 rabbit pAb

제품명

TNKS1 rabbit pAb

공급업체

ELK Biotechnology

제품 설명

TNKS1 단백질을 인식하는 토끼 유래 폴리클로날 항체입니다. Western Blot(WB) 및 ELISA 실험에 적합하며, 인간 및 생쥐 시료에서 TNKS1 단백질 검출에 사용됩니다.

제품 사양

세포 내 위치 (Cellular Localization)

Cytoplasm, Golgi apparatus membrane, peripheral membrane protein, cytoskeleton, microtubule organizing center, centrosome, nucleus (nuclear pore complex), chromosome (telomere), spindle pole. Associated with Golgi and juxtanuclear SLC2A4/GLUT4-vesicles. Minor proportion found at nuclear pore complexes and pericentriolar matrix of mitotic centromeres. During interphase, a small fraction is in the nucleus associated with TERF1. Localizes to spindle poles at mitosis onset via interaction with NUMA1.

Background

• Catalytic activity: NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor
• Function: Regulates vesicle trafficking and modulates subcellular distribution of SLC2A4/GLUT4-vesicles. Exhibits PARP activity, modifies TERF1, and contributes to telomere length regulation.
• Post-translational modifications (PTM): ADP-ribosylated (auto); phosphorylated on serine residues by MAPK kinases upon insulin stimulation.
• Similarity: Contains 1 PARP catalytic domain, 1 SAM (sterile alpha motif) domain, and 15 ANK repeats.
• Subunit interactions: Oligomerizes and associates with TNKS2; interacts with LNPEP/Otase in SLC2A4/GLUT4-vesicles; binds TERF1 via ANK repeats; found in complex with POT1, TERF1, and TINF2.
• Tissue specificity: Ubiquitous, with highest levels in testis.

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