ELK Biotechnology LITAF rabbit pAb

ELK Biotechnology LITAF rabbit pAb

제품 정보

Cellular Localization

Cytoplasm, Nucleus, Lysosome membrane, Peripheral membrane protein (cytoplasmic side), Early and Late endosome membrane, Cell membrane, Golgi apparatus membrane.
Associated with membranes of lysosomes, early and late endosomes (PubMed:11274176, PubMed:27927196, PubMed:27582497).
Can translocate from the cytoplasm into the nucleus (PubMed:15793005).
Detected at Schmidt-Lanterman incisures and in nodal regions of myelinating Schwann cells (By similarity).

Background

Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-α) and other inflammatory mediators.
This gene encodes lipopolysaccharide-induced TNF-alpha factor (LITAF), a DNA-binding protein that mediates TNF-α expression by directly binding to the promoter region of the TNF-α gene.
The transcription of this gene is induced by tumor suppressor p53 and is implicated in the p53-induced apoptotic pathway.
Mutations in this gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget’s disease (EMPD).
Multiple alternatively spliced transcript variants have been identified for this gene. [RefSeq, Dec 2014]