ELK Biotechnology GBLP rabbit pAb

GBLP rabbit pAb

제품 개요

ELK Biotechnology에서 제공하는 GBLP rabbit polyclonal antibody는 인간 단백질 일부 영역에서 유래한 합성 펩타이드를 면역원으로 제작되었습니다. 세포막 및 세포질 단백질 검출에 적합하며, WB 및 ELISA 실험에 사용 가능합니다.

제품 사양

세포 내 위치 (Cellular Localization)

• Cell membrane, peripheral membrane protein
• Cytoplasm, perinuclear region, nucleus, perikaryon
• Cell projection, dendrite, phagocytic cup
• Recruited to plasma membrane via interaction with KRT1 and ITGB1 (PubMed:17956333)
• Associated with membrane in oncogene-transformed cells (PubMed:11884618)
• PKC activation induces translocation from perinuclear region to cell periphery (PubMed:11279199)
• In brain, mainly detected in cell bodies and dendrites (By similarity)
• Localized to phagocytic cups following infection by Y. pestis (PubMed:21347310)

Background

• Domain: WD repeats domain 5 mediates interaction with TRIM63
• Function: Binds protein kinase C, anchoring activated PKC to cytoskeleton; may up-regulate kinase activity via KRT1 binding
• Complex formation: With KRT1 and ITGB1, serves as platform for SRC activation/inactivation
• Biological role: Important in developing brain and neuronal differentiation
• Similarity: Belongs to WD repeat G protein beta family; contains 7 WD repeats
• Subcellular location: Plasma membrane of neuroblastoma NMB7 cells
• Subunit interaction: Binds SLC9A3R1; forms ternary complex with TRIM63 and PRKCE; interacts with HABP4 and KRT1

제품 이미지

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