ELK Biotechnology PTPRM rabbit pAb
PTPRM rabbit pAb는 인간 및 마우스 시료에 반응하는 다클론 항체로, WB와 ELISA에 적합합니다. 세포막 단백질 PTPRM을 인식하며 세포 성장과 신호전달 연구에 유용합니다. 고순도 IgG 형식으로 -20°C에서 1년간 안정적으로 보관 가능합니다.
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ELK Biotechnology PTPRM rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | PTPRM rabbit pAb |
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:500–2000, ELISA 1:5000–20000 |
| Immunogen | Synthesized peptide derived from part region of human protein (AA range 21–61) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 159 kDa |
| Gene ID (Human) | 5797 |
| Human Swiss-Prot No. | P28827 |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein. Localizes in regions of cell-cell contact. |
| Species Reactivity | Human; Mouse |
Background
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate various cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation.
This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, representing a receptor-type PTP. The extracellular region contains a MAM domain, an Ig-like domain, and four fibronectin type III-like repeats.
PTPRM mediates cell-cell aggregation through interaction with another PTPRM molecule on adjacent cells and can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts.
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