ELK Biotechnology CFC1B rabbit pAb
CFC1B 단백질을 인식하는 rabbit polyclonal 항체로 WB와 ELISA에 사용 가능. 인간, 랫트, 마우스 반응성 확인. 1 mg/ml 농도, -20°C에서 1년 보관. 심장 기형 관련 연구 및 좌우축 형성 연구에 적합.
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제품명
CFC1B rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:500–2000, ELISA 1:5000–20000 |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Species Reactivity | Human; Rat; Mouse |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 24 kD |
| GeneID (Human) | 653275 |
| Human Swiss-Prot No | P0CG36 |
| Cellular Localization | Secreted |
| Storage | -20°C / 1 year |
| Host Species | Rabbit |
Background
Defects in CFC1 are associated with several congenital heart malformations (CTHM) including tetralogy of Fallot, pulmonary atresia, double-outlet right ventricle, truncus arteriosus communis, and aortic arch anomalies.
Mutations in CFC1 also cause transposition of the great arteries (DTGA), leading to complete inversion of the great vessels and incompatible circulatory separation, often requiring surgical intervention.
Additionally, CFC1 defects are linked to visceral heterotaxy (HTX2), characterized by complex cardiac malformations and situs inversus or situs ambiguus.
Functionally, CFC1 is involved in establishing the left-right axis and may play a role in mesoderm and neural patterning during gastrulation.
Post-translational modification includes N-glycosylation, and the protein contains one EGF-like domain.
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