ELK Biotechnology NR1H2 rabbit pAb
NR1H2 rabbit pAb는 인간, 랫트, 마우스에 반응하는 폴리클로날 항체로 WB 및 ELISA에 적합합니다. 핵 내 단백질 검출에 사용되며, 고순도 IgG 형태로 제공됩니다. -20°C에서 1년간 안정적으로 보관 가능합니다.
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NR1H2 rabbit pAb
공급업체: ELK Biotechnology
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | NR1H2 rabbit pAb |
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:500–2000, ELISA 1:5000–20000 |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Species Reactivity | Human; Rat; Mouse |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 50 kD |
| GeneID (Human) | 7376 |
| Human Swiss-Prot No | P55055 |
| Cellular Localization | Nucleus |
| Storage | -20°C / 1 year |
Background
The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]). [supplied by OMIM, Jan 2010]
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