ELK Biotechnology FKBP4 rabbit pAb
FKBP4 단백질을 인식하는 토끼 폴리클로날 항체로 WB와 ELISA에 사용 가능. 인간, 생쥐, 랫트 반응성. 세포 내 단백질 접힘 및 수송 연구에 적합. -20°C 보관, 1 mg/ml 농도.
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FKBP4 rabbit pAb
제품 개요
FKBP4 단백질을 인식하는 토끼 폴리클로날 항체입니다. 단백질 접힘 및 세포 내 수송과 관련된 연구에 적합하며, 인간, 생쥐, 랫트 시료에 반응합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | FKBP4 rabbit pAb |
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:500–2000, ELISA 1:5000–20000 |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 50 kD |
| GeneID (Human) | 2288 |
| Human Swiss-Prot No. | Q02790 |
| Species Reactivity | Human; Rat; Mouse |
| Cellular localization | Cytoplasm, cytosol, mitochondrion, nucleus, cytoskeleton, axon. Shuttles from mitochondria to nucleus; co-localizes in mitochondria with the glucocorticoid receptor (PubMed:21730050). Colocalized with MAPT/TAU in the distal part of the primary cortical neurons (By similarity). |
Background
The protein encoded by this gene is a member of the immunophilin protein family, which plays a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors.
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