ELK Biotechnology POLH rabbit pAb

제품명

POLH rabbit pAb

공급업체

ELK Biotechnology

제품 설명

POLH 단백질에 대한 토끼 폴리클로날 항체입니다. 인간 및 생쥐 시료에서 반응하며, WB 및 ELISA 실험에 적합합니다. DNA 복제 및 손상 복구 과정에서 핵 내 POLH 단백질 검출에 활용됩니다.

스펙 정보

세포 내 위치 (Cellular Localization)

Nucleus. Binding to ubiquitinated PCNA mediates colocalization to replication foci during DNA replication and persists at sites of stalled replication forks following UV irradiation (PubMed:12606586, PubMed:16357261, PubMed:24553286). After UV irradiation, recruited to DNA damage sites within 1 hour, to a maximum of about 80%; this recruitment may not be restricted to cells active in DNA replication (PubMed:22801543). Colocalizes with TRAIP to nuclear foci (PubMed:24553286).

배경 (Background)

This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

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