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ELK Biotechnology LAP2B rabbit pAb
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LAP2B rabbit polyclonal antibody for WB and ELISA applications. Recognizes human LAP2B protein localized in the nuclear inner membrane. Provides reliable detection with strong specificity and stable storage at -20°C up to 1 year.
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- pk
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ELK Biotechnology ES10928-100UL LAP2B rabbit pAb, 100UL pk판매 단위 pk ·
재고 확인 필요
402,000원VAT 포함 442,200원
ELK Biotechnology ES10928-50UL LAP2B rabbit pAb, 50UL pk판매 단위 pk ·
재고 확인 필요
301,000원VAT 포함 331,100원
ELK Biotechnology · ELK Biotechnology LAP2B rabbit pAb
ELK Biotechnology LAP2B rabbit pAb
제품 개요
LAP2B rabbit polyclonal antibody는 인간 LAP2B 단백질을 인식하며, 핵 내부막에 위치한 단백질 검출에 적합합니다. WB 및 ELISA 분석에 사용 가능하며, 높은 특이성과 안정성을 제공합니다.
제품 스펙
| 항목 | 내용 |
|---|---|
| Product name | LAP2B rabbit pAb |
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:500–2000, ELISA 1:5000–20000 |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 49 kD |
| GeneID (Human) | 7112 |
| Human Swiss-Prot No | P42167 |
| Species Reactivity | Human; Mouse |
| Cellular Localization | Nucleus inner membrane; Single-pass type II membrane protein. Tightly associated with the nuclear lamina. Isoform Zeta: Cytoplasm. |
Background
- Alternative products: Additional isoforms seem to exist.
- Domain: Two independent domains — LEM-like (LAP2-N or LEM-D) and LEM (LAP2-C or LEM-B). LEM-like binds DNA, LEM interacts with BANF1.
- Function: Involved in structural organization of the nucleus and post-mitotic nuclear assembly. Plays an important role with LMNA in nuclear anchorage of RB1.
- Role in nuclear lamina: Helps direct assembly and maintain structural organization of the nuclear envelope. Possible receptor for lamin filament attachment.
- DNA replication: May regulate initiation through interaction with NAKAP95.
- Pharmaceutical relevance: TP5 available as Timunox, Sintomodulina, and Mepentil — used for immune deficiencies, autoimmunity, infections, and cancer.
- PTM: Mitosis-specific phosphorylation abolishes binding to lamin B and chromosomes; phosphorylated in a mitosis-specific manner.
- Similarity: Member of LEM family; contains 1 LEM domain and 1 LEM-like domain.
- Subcellular location: Diffuse nuclear expression; tightly associated with nuclear lamina.
- Subunit interactions: Interacts with LMNA, LMNB1, LMNB2, BANF1, RB1, NAKAP95, GMCL, and chromosomes.
- Tissue specificity: Expressed in many tissues; most abundant in adult thymus and fetal liver.
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