ELK Biotechnology CILP1 rabbit pAb

제품명

CILP1 rabbit pAb

공급업체

ELK Biotechnology

제품 설명

CILP1 단백질을 인식하는 토끼 유래 폴리클로날 항체입니다. 인간, 쥐, 생쥐 시료에서 반응하며, WB 및 ELISA 분석에 사용할 수 있습니다. 연골 세포외 기질 및 골관절염 관련 연구에 적합합니다.

제품 스펙

Background

Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. This gene encodes the cartilage intermediate layer protein (CILP), which increases in early osteoarthrosis cartilage. The encoded protein was thought to encode a precursor for two different proteins—an N-terminal CILP and a C-terminal homolog of NTPPHase. However, later studies identified no nucleotide pyrophosphatase phosphodiesterase (NPP) activity. The full-length and the N-terminal domain of this protein were shown to function as IGF-1 antagonists. An allelic variant of this gene has been associated with lumbar disc disease. (RefSeq, Sep 2010)