
ELK Biotechnology LPIN1 rabbit pAb
LPIN1 rabbit pAb는 인간 및 마우스에 반응하는 다클론 항체로, WB 및 ELISA에 적합합니다. 인체 유래 합성 펩타이드로 면역화되었으며, 세포질 및 핵막 등 다양한 세포 위치에서 발현되는 LPIN1 단백질 검출에 사용됩니다. -20°C에서 1년 보관 가능합니다.
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제품명
LPIN1 rabbit pAb
공급업체
ELK Biotechnology
제품 상세 정보
| 항목 | 내용 |
|---|---|
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:500–2000, ELISA 1:5000–20000 |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 97 kD |
| GeneID (Human) | 23175 |
| Human Swiss-Prot No | Q14693 |
| Species Reactivity | Human; Mouse |
| Cellular Localization | Cytoplasm, cytosol, endoplasmic reticulum membrane, nucleus membrane. Translocates from the cytosol to the endoplasmic reticulum following acetylation by KAT5. |
Background
This gene encodes a magnesium-ion-dependent phosphatidic acid phosphohydrolase enzyme that catalyzes the penultimate step in triglyceride synthesis, including the dephosphorylation of phosphatidic acid to yield diacylglycerol. Expression of this gene is required for adipocyte differentiation and it also functions as a nuclear transcriptional coactivator with some peroxisome proliferator-activated receptors to modulate expression of other genes involved in lipid metabolism.
Mutations in this gene are associated with metabolic syndrome, type 2 diabetes, and autosomal recessive acute recurrent myoglobinuria (ARARM). This gene is also a candidate for several human lipodystrophy syndromes.
Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their full-length structures have not been determined.
[provided by RefSeq, May 2012]
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