ELK Biotechnology N2DL3 rabbit pAb
N2DL3 rabbit polyclonal antibody for WB and ELISA applications. Recognizes human, rat, and mouse proteins with strong specificity. Targets NKG2D ligand-related protein involved in NK cell activation. Stable at -20°C for up to one year.
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ELK Biotechnology N2DL3 rabbit pAb
제품 개요
N2DL3 rabbit polyclonal antibody는 KLRK1/NKG2D 수용체의 리간드 중 하나인 단백질을 인식합니다. 이 단백질은 NK 세포에서 발견되며, JAK2, STAT5, ERK 신호전달 경로를 활성화합니다. 또한 여러 종양 세포 표면에서 발현되어 치료적 표적 가능성이 있습니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | N2DL3 rabbit pAb |
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:500–2000; ELISA 1:5000–20000 |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 26 kD |
| GeneID (Human) | 79465 |
| Human Swiss-Prot No | Q9BZM4 |
| Cellular Localization | Cell membrane; Lipid-anchor, GPI-anchor |
| Species Reactivity | Human; Rat; Mouse |
Background
The protein encoded by this gene is one of several related ligands of the KLRK1/NKG2D receptor, which is found in primary NK cells. Binding of these ligands to the receptor activates several signal transduction pathways, including the JAK2, STAT5, and ERK pathways. The encoded protein is expressed solubly and on the surface of many tumor cells, making it potentially an important target for therapeutics. (RefSeq, Nov 2015)
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