Thermo Fisher Scientific TPMT Monoclonal Antibody (OTI4C1)
TPMT 단백질을 인식하는 Mouse IgG1 단클론 항체로, Western blot, IHC, Flow cytometry 등 다양한 응용 가능. 인간 및 개 시료 반응성. 고순도 Affinity Chromatography 정제, 안정적 액상 형태로 연구용에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Dog, Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4C1 |
| Immunogen | Full length human recombinant protein of TPMT produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.88 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2725547 |
Target Information
TPMT (Thiopurine S-methyltransferase) catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine. Defects in TPMT cause thiopurine S-methyltransferase deficiency, leading to toxicity risks in patients with low TPMT activity. TPMT plays a crucial role in the metabolism and inactivation of thiopurine drugs, commonly used as immunosuppressants or cytotoxic agents for conditions like leukemia, autoimmune diseases, and organ transplantation. Genetic variations at the TPMT locus largely determine inter-individual drug response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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