Thermo Fisher Scientific PRR5L Polyclonal Antibody
PRR5L 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. 인간 시료에 반응하며 ICC/IF 실험에 적합. 고순도 항원 친화 크로마토그래피 정제. 장기 보관 시 -20°C에서 안정적 유지.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human PRR5L (Control fragment: Product #RP-107733) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2663672 |
Product Specific Information
- Immunogen sequence: RQCSSEPNITD NPDGLEEGAR GSQEGSELNC ASLS
- Highest antigen sequence identity to orthologs: mouse 73%, rat 73%
Target Information
Proline-rich protein 5-like (PRR5L), also known as Protor-2, is structurally similar to PRR5 and binds to the mTOR complex 2 (mTORC2).
PRR5L is not required for mTORC2 integrity or kinase activity but dissociates from mTORC2 upon knockdown of tuberous sclerosis complex 1 (TSC1) and TSC2.
Knockdown of PRR5L reduces apoptosis in mTORC2-deficient cells and in cells where mTOR is active, suggesting that mTORC2-dissociated PRR5L may promote apoptosis and play a role in balancing cell growth and death.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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