Thermo Fisher Scientific DBC2/RHOBTB2 Monoclonal Antibody (DBC2/3361)

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Antibody is stable for 24 months.
• Positive Control: Human heart muscle or brain tissue
• Cellular Localization: Secreted in plasma

Specificity Comments:
The Rho subfamily of Ras-related GTPases controls multiple aspects of cell function, including cytoskeletal rearrangement, nuclear signaling, and cell growth. DBC-2 (deleted in breast cancer 2 gene protein), also known as RHOBTB2 (Rho-related BTB domain-containing protein 2), is a 727 amino acid member of the RhoBTB subfamily of Rho GTPases. Members of the RhoBTB subfamily are evolutionarily conserved and characterized by a proline-rich region, a GTPase domain, and two tandem BTB repeats.

Expressed ubiquitously with highest levels in neural tissue, heart, brain, and fetal lung, DBC-2 contains two BTB (POZ) domains through which it may bind to and regulate target proteins such as CUL-3. DBC-2 is thought to function as a regulator of cell cycle and apoptosis events and exhibits tumor suppressor activity under normal conditions. Mutations in the DBC-2 gene are associated with breast cancer, suggesting a role in carcinogenesis.

Target Information

RHOBTB2 is a member of the evolutionarily conserved RHOBTB subfamily of Rho GTPases. For background information on RHOBTBs, see RHOBTB1.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.