Thermo Fisher Scientific ERCC6L Polyclonal Antibody, MaxPab

Applications

Western Blot (WB)

• Tested Dilution: 1–5 µg/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:

MEKSFATKNE AVQKETLQEG PKQEALQEDP LESFNYVLSK STKADIGPNL DQLKDDEILR 
HCNPWPIISI TNESQNAESN VSIIEIADDL SASHSALQDA QASEAKLEEE PSASSPQYAC 
DFNLFLEDSA DNRQNFSSQS LEHVEKENSL CGSAPNSRAG FVHSKTCLSW EFSEKDDEPE 
EVVVKAKIRS KARRIVSDGE DEDDSFKDTS SINPFNTSLF QFSSVKQFDA STPKNDISPP 
GRFFSSQIPS SVNKSMNSRR SLASRRSLIN MVLDHVEDME ERLDDSSEAK GPEDYPEEGV 
EESSGEASKY TEEDPSGETL SSENKSSWLM TSKPSALAQE TSLGAPEPLS GEQLVGSPQD 
KAAEATNDYE TLVKRGKELK ECGKIQEALN CLVKALDIKS ADPEVMLLTL SLYKQLNNN

Target Information

ERCC6L is a DNA helicase that acts as an essential component of the spindle assembly checkpoint.
It contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin.
ERCC6L acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.