Thermo Fisher Scientific MTDH Monoclonal Antibody (OTI1H1), TrueMAB
MTDH 단백질을 인식하는 Mouse monoclonal antibody로 Western blot 및 IHC(P)에서 검증됨. Human 시료에 반응하며, 1 mg/mL 농도의 액상 제품. PBS/BSA/glycerol buffer에 보관되며, -20°C에서 냉동 보관 권장. 암 전이 연구 등에서 MTDH 발현 분석에 활용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1H1 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 70–582 of human MTDH produced in SF9 cell. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Metadherin (Metastasis adhesion protein), also known as MTDH or LYRIC, is a novel protein that localizes with tight junction proteins ZO-1 and occludin in polarized epithelial cells.
It is recruited during the maturation of the tight junction complex rather than acting as a structural component.
Metadherin is overexpressed in breast cancer tissue and xenografts, while normal breast tissue shows much lower expression.
It binds to lung vasculature, a common site of breast cancer metastasis, through a C-terminal extracellular segment.
Blocking this domain with antibodies or inhibiting metadherin via siRNA has been reported to inhibit breast cancer metastasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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