Thermo Fisher Scientific PGP9.5 Polyclonal Antibody
Rabbit polyclonal antibody targeting PGP9.5 (UCH-L1), reactive with human, non-human primate, and rat. Suitable for Western blot applications. Supplied as a liquid, protein G purified, stored at 4°C or -20°C. For research use only.
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Applications
- Western Blot (WB): 0.1–0.5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues 100–150 of human Uch-L1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 0.2% gelatin |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2210648 |
Target Information
PGP9.5 (Protein Gene Product 9.5, also known as UCH-L1 or PARK5) is a neuron-specific protein distinct from neuron-specific enolase. It has a molecular weight of approximately 27 kDa and belongs to the ubiquitin carboxyl-terminal hydrolase family (peptidase family C12). PGP9.5 exhibits both ubiquitin hydrolase and ligase activities, playing a critical role in ubiquitin recycling.
This protein is expressed in neurons and nerve fibers throughout the central and peripheral nervous systems, as well as in neuroendocrine cells, renal tubules, spermatogonia, Leydig cells, ova, and corpus luteum cells. Overexpression of PGP9.5 has been associated with non-small cell lung cancer, while reduced expression is linked to Huntington’s and Alzheimer’s diseases. Due to its neuronal specificity, PGP9.5 serves as a useful marker in studies of neurodegenerative disorders such as Parkinson’s disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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