Thermo Fisher Scientific ABCB1 Monoclonal Antibody (OTI9C10), TrueMAB
ABCB1 단백질을 인식하는 마우스 단클론 항체로, Western blot, IHC, Flow cytometry에 사용 가능. 인간 시료 반응성, 비결합형 액상 항체이며 친화 크로마토그래피로 정제됨. 약물 내성 연구 및 ABC 수송체 분석에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution | Reference |
|---|---|---|
| Western Blot (WB) | 1:2,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:2,000 | - |
| Flow Cytometry (Flow) | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI9C10 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 995–1280 of human ABCB1 produced in SF9 cell. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The membrane-associated protein encoded by this gene is a member of the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes and are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).
This protein belongs to the MDR/TAP subfamily, which is involved in multidrug resistance. It acts as an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity, contributing to decreased drug accumulation in multidrug-resistant cells and mediating resistance to anticancer drugs. Additionally, it functions as a transporter in the blood-brain barrier.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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