Thermo Fisher Scientific LILRB2 Polyclonal Antibody
Human LILRB2 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, ICC/IF, ELISA에 사용 가능. 고순도 친화 크로마토그래피 정제, PBS/glycerol buffer 포맷. 세포막 단백질 검출에 적합하며 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 5 µg/mL |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 479–598 of human LILRB2/CD85d/ILT4 (NP_0058653) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.15 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804871 |
Product Specific Information
- Immunogen sequence:
LFLILRHRRQ GKHWTSTQRK ADFQHPAGAV GPEPTDRGLQ WRSSPAADAQ EENLYAAVKD TQPEDGVEMD TRAAASEAPQ DVTYAQLHSL TLRRKATEPP PSQEREPPAE PSIYATLAIH - Positive Samples: THP-1, U-87MG
- Cellular Location: Membrane, Single-pass type I membrane protein
Target Information
LILRB2 (ILT4) gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, located in the chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors, containing two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs).
This receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It helps regulate inflammatory responses and cytotoxicity, controlling immune balance and limiting autoreactivity.
Multiple transcript variants encoding different isoforms have been identified.
Safety and Regulatory Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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