Thermo Fisher Scientific Phospho-Btk (Tyr223) Polyclonal Antibody
인간 BTK 단백질의 Tyr223 인산화 부위를 인식하는 폴리클로날 항체입니다. Western blot에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며, -20°C에서 보관합니다. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific Phospho-Btk (Tyr223) Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Chemically synthesized phosphopeptide derived from the region of human BTK containing tyrosine 223 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Dulbecco’s PBS (pH 7.3) with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533597 |
Target Information
Bruton tyrosine kinase (BTK) is a cytoplasmic tyrosine kinase belonging to the SRC-related TEC subfamily of tyrosine kinases. Mutations in the BTK gene have been linked to severe developmental blocks in human B-cell ontogeny and immunodeficiency disorders.
BTK interacts with members of the toll-like receptor (TLR) family such as TLR4, 6, 8, and 9, which are critical in innate and adaptive immunity. It also interacts with key proteins in TLR4 signal transduction such as MyD88, TIRAP, and IRAK, but not TRAF-6, suggesting involvement in lipopolysaccharide signal transduction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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