Thermo Fisher Scientific PAI1 Polyclonal Antibody

Applications

• ELISA (ELISA)
  Tested Dilution: 5–10 µg/mL

Product Specifications

Product Specific Information

PA1-75353 specifically detects Plasminogen Activator Inhibitor 1 (PAI1).
It has been successfully used in ELISA applications.
The immunogen used is recombinant human PAI-1.

Target Information

PAI1 (plasminogen activator inhibitor 1) belongs to the serine protease inhibitor superfamily and is the principal inhibitor of tissue-type and urokinase-type plasminogen activators (tPA and uPA).
Platelets are the main source of circulating PAI1, but it is also synthesized and secreted by various tissues and cell types including fibroblasts, smooth muscle cells, endothelial cells, hepatocytes, and inflammatory cells.

Expression of PAI1 can be regulated at the transcriptional level by multiple factors such as growth factors, cytokines, hormones, inflammatory mediators, glucose or lipid metabolites, vascular tone regulators, chemicals, and environmental or physical stimuli.
Elevated PAI1 levels are associated with increased thrombosis risk in obesity, thrombophilia, and metabolic syndrome.
Defects in PAI1 cause abnormal bleeding and are linked to plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency).
PAI1 inhibits fibrinolysis by blocking plasminogen activator activity and may also promote neuronal survival.
Alternatively spliced transcript variants encoding different isoforms of PAI1 have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.