Thermo Fisher Scientific MSRA Polyclonal Antibody
MSRA 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC(P), ICC/IF에 사용 가능. 고순도의 항원 친화 크로마토그래피 정제 제품이며, -20°C에서 보관. 세포 산화 손상 연구 및 Alzheimer’s disease 관련 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5–20 µg/mL |
| Immunocytochemistry (ICC/IF) | 5–20 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein Methionine Sulfoxide Reductase A (amino acids 27–235 of target protein) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 500 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2903780 |
Target Information
Methionine sulfoxide reductase (MsrA) reduces methionine sulfoxide (MetO) residues in proteins and free MetO to methionine (Met).
The catalytic activity of MsrA is dependent on bound metal and cofactors, requiring reducing equivalents from either DTT or a thioredoxin-regenerating system.
MsrA plays an essential role in protecting cells against oxidative damage.
Known substrates include calmodulin, HIV protease, and α1-proteinase inhibitor.
Recent studies indicate a connection between MsrA and Alzheimer’s disease in mammals.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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