Thermo Fisher Scientific Amitryptyline Polyclonal Antibody

Applications

Tested Dilution

Publications

ELISA (ELISA)

5-10 µg/mL

-

Product Specifications

Species Reactivity

Chemical

Host/Isotype

Sheep / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Amitriptyline-BTG

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Purification

purified

Storage buffer

PBS, pH 7.4

Contains

0.09% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_1089626

Product Specific Information

Working Concentration: 2.5 µg/mL. Sensitivity: 10 ng/mL Amitriptyline produces 67% inhibition in a competitive ELISA employing Tricyclic Antidepressants (TCA) (1) polyclonal antibody.

Target Information

Amitriptyline is a Tricyclic Antidepressant that inhibits the re-uptake of norepinephrine and serotonin by the presynaptic neuronal membrane in the central nervous system (CNS), thereby increasing the synaptic concentration of norepinephrine and serotonin. Due to constant stimulation to these receptors, amitriptyline may produce a downregulation of adrenergic and serotonin receptors, which may contribute to the antidepressant activity. [National Center for Biotechnology Information. PubChem Compound Database; CID=2160].

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.