Thermo Fisher Scientific CA19-9/Sialyl Lewisa (GI Tumor Marker) Monoclonal Antibody (121SLE)
GI 종양 마커 CA19-9/Sialyl Lewis A를 인식하는 단클론 항체로, 인간 시료에 반응. IHC(P) 및 IHC(PFA) 실험에 적합. 단백질 A/G 정제, 액상 형태로 제공. 연구용으로만 사용 가능.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgM, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 121SLE |
| Immunogen | Precipitin lines obtained after immuno-diffusion using MAb 116-NS-19-9 and mucins isolated from an ovarian cyst of a Lewis A+B- patient (0Le). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage conditions | 4°C, do not freeze |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
Mucin glycoprotein is a Sialyl Lewis A structure synthesized from type 1 blood group precursor chains and is present in individuals expressing the Lewis A and/or Lewis B blood group antigens.
In normal tissues, sialyl Lewis A antigen is found in ductal epithelium of the breast, kidney, salivary gland, and sweat glands.
Its expression is greatly enhanced in serum and in most tumor cells of gastrointestinal (GI) carcinomas, including adenocarcinomas of the stomach, intestine, and pancreas.
Preoperative elevated CA19-9 levels in patients with stage I pancreatic carcinoma decrease to normal values following surgery.
When used serially, CA19-9 can predict recurrence of disease prior to radiographic or clinical findings.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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