Thermo Fisher Scientific TrxR2 Polyclonal Antibody
Human TrxR2 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot과 IHC(P)에서 검증됨. 항원 친화 크로마토그래피로 정제되었으며, PBS(40% glycerol) 용액 형태로 제공. 세포 내 산화환원 조절 연구에 적합.
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- PA582080
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- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human TXNRD2. Recombinant protein control fragment (Product #RP-91355). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2789241 |
Product Specific Information
Immunogen sequence:
CAGFLTGIGL DTTIMMRSIP LRGFDQQMSS MVIEHMASHG TRFLRGCAPS RVRRLPDGQL QVTWEDSTTG KEDTGTFDTV LWAIGRVPDT RSLNLEKAGV DTSPDTQKIL VDSREATSVP HIYAIGDVVE GRPELTPTAI MAGRLLVQRL F
Target Information
The mammalian thioredoxin reductases (TrxRs) are a family of selenocysteine-containing pyridine nucleotide–disulfide oxidoreductases. All mammalian TrxRs are homologous to glutathione reductase with respect to primary structure, including the conserved redox catalytic site (-Cys-Val-Asn-Val-Gly-Cys-), but distinctively possess a C-terminal extension containing a catalytically active penultimate selenocysteine (SeCys) residue in the conserved sequence (-Gly-Cys-SeCys-Gly-).
TrxR is a homodimeric protein in which each monomer includes an FAD prosthetic group, an NADPH binding site, and a redox catalytic site. Electrons are transferred from NADPH via FAD and the active-site disulfide to the C-terminal SeCys-containing redox center, which then reduces substrates such as thioredoxin.
Members of the TrxR family are 55–58 kDa in size and include three isoforms: cytosolic TrxR1, mitochondrial TrxR2, and TrxR3 (also known as Trx and GSSG reductase, TGR). TrxR plays a key role in protecting cells against oxidative stress and in redox regulation of transcription factors and various biological processes.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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